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NF-B activation by peroxynitrite through IB-dependent phosphorylation versus nitration in colon cancer cells

This can be induced by phenomena such as oxidative stress, mitochondrial damage, and the generation of DAMPs, which activate the NLRP3 inflammasome

Subsequently, articles have also reported that HABN containing adriamycin (DOX@HABN) showed significant tumor targeting and synergistic anti-tumor capabilities in HeLa-loaded mice (229)

In oxidation, first of all, the drug is attached to CYP-450 to form a complex

As a typical amphiphilic structure, LNPs can simultaneously load both hydrophilic and hydrophobic drugs, thereby mimicking natural cell membranes and significantly enhancing cellular uptake and endocytosis processes (45)