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Use vendors with third-party COA (98% purity)

If you experience any irritation, discontinue use and consult a dermatologist

Published descriptions vary slightly in reported length, so for the exact chemical identity check the PubChem entry rather than relying on a single secondary source

QZ: Methodology, Writing review and editing

The relevance here is evidential, not procedural: because delivery and stability vary so much, comparing results across products and studies is genuinely difficult, and that heterogeneity is one reason a clean answer to the title question has been so slow to emerge

For the kind of significant structural remodeling needed after losing 50 or more pounds, topical alone is unlikely to produce dramatic results