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injections of 100 nmol kg 1 MK-801 ( n = 10), 100 nmol kg 1 GLP-1 ( n = 10), 100 nmol kg 1 GLP-1MK-801 ( n = 10) or vehicle (isotonic saline, n = 10) for 14 days

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Visible body composition changes reduced body fat (particularly midsection), increased lean muscle tone, improved skin elasticity, and measurable IGF-1 improvements on follow-up blood work

All analyses were performed using GraphPad Prism software v

185 The association of ERK1/2 on the epithelial barrier and the homeostasis of TJ has been a subject of ongoing investigation