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Taken together, these in vivo data from multiple CRC models support our conclusion that inhibition of mitochondrial metabolism by metformin treatment can enhance the response of 5FU treatment by increasing tumour cell death and impeding tumour growth

Golant BT, Velez-Perez A, Krishnamurthy S, Guo M, Mousavi S, Hu MI, Varghese JM, Zafereo ME , Debnam JM

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Deshmukh, L., Tugarinov, V., Appella, D