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This hindrance in timely identification is compounded by individuals frequent oversight of symptoms and the potential misinterpretation by primary care physicians [34]

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High levels of HEY2 recruit HDAC1 to the promoters of PGC-1 coactivator complex genes and carnitine palmitoyltransferase 1A/2 ( CPT1A/2 ) regulatory genes to mediate histone deacetylation and transcriptional repression, which results in decreased energy production, increased ROS levels, and cardiac dilation and failure

A few commenters also agreed that PRO-PMs like this one provide valuable insights into the effectiveness of communication with patients and patient satisfaction and can help identify opportunities for improvement in perioperative care