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Studies were included based on relevance to predefined thematic areas, including mechanistic pathways of ototoxicity, pharmacokinetic and pharmacodynamic considerations, genetic susceptibility, and clinical outcomes

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Louis, MO, USA) and goat Anti-rabbit IgG/Alexa Fluor 647 antibody (#bs-0295G-AF647, 1:500) was purchased from Bioss (Woburn, MA, USA)