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Other mechanisms contributing to resistance include MET amplification, human epidermal growth factor receptor (HER)2 amplification, histologic transformation into SCLC, and activation of alternative signaling pathways (5964)

The scientific literature demonstrates pesticides long history of severe adverse effects on human health (i.e., endocrine disruption, cancer, reproductive/birth problems, neurotoxicity, loss of biodiversity, etc.) and wildlife and biodiversity

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Effects depend on the dose, the form, the duration of exposure, and individual genetics

Elastin, decorin, and glycosaminoglycan synthesis increase

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