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found that a silybinphosphatidylcholine complex in oily-medium soft-gel capsules provided superior bioavailability compared to conventional silymarin tablets ( 5.5 Cyclodextrin inclusion complexes Cyclodextrins (CDs) enhance silymarin solubility and dissolution, with HP--CD increasing solubility 20-fold and oral bioavailability 2.02.1-fold in rats ( 5.6 Lipid nanoparticles Lipid-based nanoparticles such as solid lipid nanoparticles (SLNs) and NLCs have the potential to protect against enzymatic degradation by lipases and release in a controlled manner and via a lymphatic path of delivery

Mutant OPTN promotes the expression of downstream target genes of NF-B, such as p53 and proapoptotic proteins, to induce cell death by triggering p53-dependent apoptosis

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Am J Physiol Cell Physiol (2007) 293:C14818

Kim-Muller, J

Complex lipid extraction and MS analysis The organic layer from Folch extraction was dried, reconstituted in 9:1 methanol and chloroform and analyzed on a Waters Acquity UPLC/Thermo Lumos Orbitrap using a CSH C18 column in both positive and negative ionization modes