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Necroptosis can also be materialized as a result of activation of the signaling pathways, due to DNA damage, which leads to the release of apoptosis-related factors from the mitochondrial intermembrane space, followed by the activation of the DNA damagerelated enzyme poly(ADP-ribose) polymerase (PARP) [213]

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6a) and found that 8 of them were solubilised in ZIL and/or ZIL aqueous solution (ZIL aq.) (50, 25, or 5%, w/v), including zoledronic acid monohydrate, which is soluble in neither water nor DMSO (Supplementary Fig

5c), capable of producing 13.9 g/L glutarate from 20 g/L glutaraldehyde in 30 h, representing a 5.6-fold improvement over wild-type ALDH