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PMCID: PMC6562654

1 There are four well-known SNPs (rs6269, rs4633, rs4818, and rs4680) found in the COMT gene that contribute to low, average, and high pain sensitivity phenotypes

However, as discussed later, it is possible that the macronutrient distribution of the MedDiet could be manipulated on a day-by-day or session-by-session basis by altering the amounts of different foods which are typically consumed as part of this dietary pattern

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/-103015And/or, the reaction temperature is -10C to 30C, preferably 15C

Finally, to confirm whether metformin also increased GLUT1 expression in the human intestine, human intestinal organoids were treated with metformin, and GLUT1 expression was compared