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The impaired function of the mitochondrial respiratory chain leads to overproduction of ROS and cytokines, which triggers lipid peroxidation

The two major homocysteine-utilizing enzymes, methionine synthase and cystathionine -synthase, show reciprocal sensitivity to oxidative conditions (Mosharov et al., 2000)

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The implementation of sensitive biomarker tests and accredited clinical indices in routine practice is pivotal towards accurate disease monitoring as well as effective therapeutic management