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Price incentives like discounts, coupons, and sampling can undercut the impact of excise taxes and other proven effective tobacco control measures that raise the cost of tobacco products, which previous research shows is one of the strongest deterrents to initiation and progression of tobacco use, particularly among price-sensitive groups

While smoking's harmful effects on the lungs are well established, the biological processes that connect cigarette smoke exposure to cardiovascular disease have been less well understood

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In addition, while long-term health effects of vapes need to be studied further, the double exposure to large amounts of nicotine and toxicants from both conventional cigarettes and vapes are a great concern for public health. Future Research Directions The researchers say that because they were combining several studies, each with a slightly different approach, it was not possible to categorize different types of dual use, such as people who mostly smoke but occasionally vape

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While 6MN may be the first analog requiring regulatory consideration, the near term use of other nicotinoid compounds seems certain