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10.1016/j.trsl.2019.03.004 13 DerbaliA.MnafguiK.AffesM.DerbaliF.HajjiR.GharsallahN.et al (2015)

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Similarly, the metal-responsive transcription factor MTF-1 accumulates in the nucleus upon zinc elevation, binding to metal-response elements to induce MT and other protective genes, thus forming a feedback loop that mitigates zinc excess 54,55

Monoamine oxidase (MAO) is a riboflavin protein distributed on the outer membrane of mitochondria, which catalyzes the oxidative deamination of neurotransmitters such as dopamine, phenethylamine, 5-hydroxytryptamine, and norepinephrine (Tripathi and Ayyannan, 2019)

Once produced, NO rapidly permeates cell membranes and functions as a potent paracrine signaling molecule