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1,140 (n) 2,815 (n) Wang 35% 0.65 [0.30-1.40] severe case n/a n/a Mendelian - per SD Voloudakis 19% 0.81 [0.72-0.92] cases population-based cohort Tau 2 = 0.04, I 2 = 66.3%, p = 0.0025 Prophylaxis 31% 0.69 [0.55-0.88] 36/1,472 714/20,067 31% lower risk All studies 33% 0.67 [0.51-0.88] 63/1,768 784/20,499 33% lower risk 14 vitamin A COVID-19 studies c19 early .org July 2026 Tau 2 = 0.10, I 2 = 66.1%, p = 0.004 Effect extraction pre-specified (most serious outcome, see appendix) 1 CT: study uses combined treatment Favors vitamin A Favors control Download Image 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Al-Sumiadai 86% 0.14 [0.03-0.61] 2/70 14/70 Improvement, RR [CI] Treatment Control Tau 2 = 0.00, I 2 = 0.0%, p = 0.0083 Early treatment 86% 0.14 [0.03-0.61] 2/70 14/70 86% lower risk Sarohan -282% 3.83 [1.58-9.24] 9/10 4/17 Improvement, RR [CI] Treatment Control Beigm

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