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The FDA warns that both CJC-1295 and ipamorelin are risky for immunogenicity, potentially causing life-threatening outcomes such as anaphylaxis.25 26 Cardiovascular concerns: Specifically concerning CJC-1295, the FDA warns of the risk of increased heart rate and systemic vasodilatory reaction, including flushing, warmth, and transient hypotension.25 27 Cancer: With their ability to increase the rate of cellular replication, growth hormone secretagogues in general are unsafe for cancer survivors and people with an active cancer diagnosis.28 Secretagogue use may elevate their risk for recurrence or worsen their prognosis

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Daily use may help improve the visible texture and brightness of the skin over time

PMID: 3569762, DOI: 10.1016/0016-5085(87)90618-4

Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl

Furthermore, because of the possibility of adverse effects on a nursing infant, this therapy is generally avoided in women who are breastfeeding