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4.1
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Description

Of note, levels of CII-specific IgG, IgG2a and IgG2b were not changed by the zonulin antagonist (Supplementary Fig

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Budnitz, D

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10.1161/CIRCRESAHA.120.316242 88 YanH.AjuwonK

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Mitochondrial DNA damage and apoptosis by ROS Apoptosis is generally induced by the activation of cell surface death receptors (exogenous pathways) that are initiated mainly by the binding of death ligands of the TNF superfamily of cytokines, including TNF, Fas-ligand, and TNF-related apoptosis-inducing ligand with their death receptors TNF receptor 1, Fas (also known as CD95), and DR4 or DR5, respectively

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295 This indicates that Trx acts as an upstream inhibitor of ASK1, and Trx/ASK1 signalling is an upstream modulator of p38MAPK

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