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Trial design This was a single-arm, open-label pilot trial to assess the feasibility, efficacy, and safety of utilizing imiquimod 5% cream applied topically in a neoadjuvant setting for 28 days immediately followed by surgical resection of the tumor

An empty stomach reduces enzymatic breakdown and may improve peptide transport across the gut lining

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The outer abdomen, particularly the lower quadrants, contains substantial fat even in relatively lean individuals

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The absorption of this essential vitamin decreases when gastric emptying slows dramatically