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All reactions were then mixed gently and centrifuged before incubation for 20 h overnight at 37 C

Acknowledgements We thank Dr James Perkins for help with the final English language version of this manuscript

phosphorylation of Thr806 in SPT5 and also in the CTD of RNAPII were decreased after CDK9 inhibition 80,87,88 , and modest changes in phosphorylation of Ser2 and Ser7 were detected upon longer ( 1 h) CDK12/13 inhibition 78,81,89,90,91,92,93,94,95 (Fig

Iron deficiency: It may interfere with iron absorption

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