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10.1038/s41380-021-01160-8 70

liwiska-Kowalska and Zaborowski, 2017)

Excess metabolites induce hepatocyte stress, injury and death, which subsequently leads to hepatic insulin resistance, changes in the gut microbiota, and other harmful phenomena, such as mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, and the generation of reactive oxygen species (ROS)