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24 for the corresponding loop in MPGES1 (denoted C-loop) a direct amino acid interaction to the GSH from this loop was not observed in the MPGES1 X-ray structure (PDB ID: 4AL0) and can neither be found in the MPGES1 structure obtained by 2D-crystallography (PDB ID: 3DWW) 26

This review does not follow a systematic review protocol but aims to provide a comprehensive and integrative overview of current knowledge in this field

Sina Gallo delivered a seminar presentation to colleagues at the Arkansas Childrens Nutrition Center in Little Rock, AR on Friday, September 13th

quadrangularis)

Moreover, ChiC and ChiE contain conserved cysteines that form a reversible disulfide bond, suggesting redox-sensitive regulation of ligand interaction, as confirmed by structural data and the Ellman assay (Table S4)