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Lemanske RF Jr, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, et al

mtDNA: sensing and immune activation Under physiological conditions, mtDNA is securely sequestered within the mitochondrial matrix

(2023) "Advances in anti-obesity pharmacotherapy: current treatments, emerging therapies, and challenges." Cureus 15(10)

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Common (Usually Transient) Side Effects Water retention or puffiness Carpal tunnel-like symptoms Joint stiffness (often temporary) Mild insulin resistance if overdosed How We Monitor Baseline and follow-up IGF-1 levels Body composition changes Symptom tracking and dose titration Our goal is to maintain IGF-1 in the high-normal physiologic range , not to create supraphysiologic levels