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However, mass spectrometry, while advantageous for analyzing whole cell association, has principal limitations as currently reported: (a) restricted throughput capacity and (b) would ambiguously define molecule location unless additional, careful fractionation methods are included to show periplasmic or cytoplasmic accumulation 18 , and (c) needs compounds to be mass active

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Although there are limited studies on their pathophysiological role in cancer, increased expression of mitoferrins associated with tumor proliferation and worse prognosis [28]

T-cells have a low baseline supply of cysteine, even under healthy physiological conditions

Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target

Plasma syndecan-1, a marker of endothelial glycocalyx injury and a predictor of mortality in severe sepsis and acute respiratory distress syndrome, was significantly reduced following HDIVC treatment (Kashiouris et al., 2019)