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doi: 10.1016/S0896-6273(00)00166-5 48 ChenW.ZhangY.LiangJ.ZhangZ.ZhangL.HuangE.et al

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364 Emodin can relieve collagen-induced joint inflammation in rats by inhibiting ferroptosis and degrading MMP

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Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis

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Ng S-W, Norwitz SG, Taylor HS, Norwitz ER

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This triggers collagen synthesis , attracts immune cells, promotes blood vessel formation, and activates dozens of genes involved in tissue repair

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TH1 cells release IFN-gamma which recruits and activates macrophages

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