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Ovarian GH-IGF Axis Interaction of GH with GHR can activate canonical and non-canonical downstream signaling

We revealed the molecular mechanism involved in the leptin-induced transcriptional regulation of carnitine palmitoyl transferase 1b ( Cpt1b ) and long-chain acyl-coenzyme A synthetase 1 ( Acsl1 ) using transfection/reporter assays and chromatin immunoprecipitation

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doi: 10.1016/j.clinre.2023.102221

Phosphorylation sites with missing values in more than 50% of samples were filtered out and the following key parameters were used: weight = 0, statistic = area.under.RES, output.score.type = NES, nperm = 1000 and min.overlap = 5