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They pored through the existing literaturechemistry and toxicology studies, human clinical trials and epidemiological studies, and even internal tobacco company documentsand uncovered what they believe is the culprit behind the rates of lung adenocarcinoma

Cigar smokers are about 27 times more likely than nonsmokers to have oral cancer, 15 times more likely to have cancer of the esophagus and 53 times more likely to have cancer of the larynx, the ALA says

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However, the use and safety of e-cigarettes is highly controversial

"It is not the same as having a limited number of tobacco shops, which are a fixed number and are under the control of a public monopoly that limits the rules of the game", he compares

Duke: Master Builder , p