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Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

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IM injections into the same muscle group create cumulative microtrauma that alters local blood flow and lymphatic drainage, which degrades absorption consistency by week 46 of a protocol

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