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Recessive Epidemiology: 4 patients Genetics Mutations: Missense & Stop NDUFA6 protein Mitochondrial inner membrane Complex I assembly Clinical Onset age: Prenatal to 2 years Prenatal: Growth retardation Hypotonia Weakness Arms & Legs Dysphagia May become severe Spasticity: Some patients Optic atrophy Seizures (50%) Course Progressive Some exacerbations with fever Death 10 families Genetics Mutations: Missense Female carriers: Mild phenotype HSD17B10 protein Mitochondrial matrix enzyme Multifunctional moonlighting protein: Involvement in multiple biochemical pathways Isoleucine metabolism Short-chain dehydrogenase/reductase: Preference for short-chain methyl-branched acyl-CoA Subunit of mt-RNase P complex tRNA maturation

The language of the statutory budget neutrality requirement permits the agency to implement the budget neutrality provision in this manner

There was significant increase observed in groups treated with DLX, ALA and in combination groups compared to surgery control Fig

82,103 As an NAD + -dependent deacetylase, SIRT1 regulates glucose metabolism and insulin sensitivity through multiple signaling axes, alleviating systemic metabolic imbalance

10.21315/tlsr2023.34.3.13 134 TianW.XiaoN.YangY.XiaoJ.ZengR.XieL.et al (2020)