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Adherence to metformin and the onset of rheumatoid arthritis: a population-based cohort study

Simultaneously, they can enhance the activity of other antioxidant components, synergistically producing antioxidant effects and inhibiting the oxidative stress-induced apoptosis process of photoreceptor cells through multiple pathways (Shao et al., 2019)

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Considering that ROS impacts the activities of epigenetic modulators 129,130,131 , it is reasonable to hypothesize that high levels of ROS generated by increased metabolic rate, gene mutation and relative hypoxia 117 perhaps explain the DNA hypomethylation and GPX7 overexpression seen in gliomas