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Moreover, many tumors including PCa cells shed DNA into the serum or other easily accessible body fluids (e.g., semen, urine), simplifying the detection of GSTP1 epimutations in early tumorigenesis stages

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Mechanistically, DUSP4-mediated phosphorylation of YTHDC1 at threonine residue T148 enhances its binding to SRSF3, thereby reducing nuclear retention of FTH1/FTL mRNA