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Early programmes, institutional studies, and preclinical model work examined how the compound class might influence receptor signalling, cellular adaptation, or tissue-level response patterns under controlled conditions

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Heffernan, Jiang, Thorburn, and Ng reported in the American Journal of Physiology that oral administration of AOD9401 to ob/ob mice was associated with reduced body-weight gain, altered adipose lipogenic and lipolytic activity, and acute changes in energy expenditure, evidence that a growth-hormone C-terminal fragment could act after oral delivery in a rodent model [3]

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