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This prevents megaloblastic anemia by ensuring proper red blood cell maturation, with hemoglobin levels increasing by 1-2 g/dL within 2-3 months of supplementation in 80% of deficient cases (per 2025 WHO meta-analysis)

297,298,299,301 Subsequent trials in patients with T2D and established HF showed that dapagliflozin and empagliflozin reduced the composite outcomes of worsening HF (defined as hospitalization for HF or an urgent visit for HF) or cardiovascular death by 2126%