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It promoted immune tolerance and alleviated allergic symptoms by upregulating IL-2 and INF- levels while reducing CD4 + and Foxp3+ Treg cell counts (Zhang et al., 2019a)

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The PNPLA3 gene encodes for the membrane bound PNPLA3 enzyme, which is mainly expressed in the liver (where it is involved in hepatic steatosis) and adipose tissue (where it mediates acylglycerol hydrolysis)