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Retatrutide does not currently hold a marketing authorisation from the MHRA or EMA and is not legally available as a prescribed medicine in the UK outside of approved clinical trial settings

In such cases, an injection bypasses the gut and delivers B12 directly into the bloodstream

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Acute leukoencephalopathy possibly induced by phenytoin intoxication in an adult patient with methylenetetrahydrofolate reductase deficiency

Other populations at risk include people who had gastrointestinal surgery (including weight loss surgery) and diseases that affect the gut, such as Crohn's disease or celiac disease