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Ideally incorporate rigorous baseline and follow-up assessments: DEXA, body composition, visceral fat, renal function, endocrine panels, inflammatory biomarkers (IL-6, TNF-, SASP markers if available)

Transient nutrient deprivation promotes macropinocytosis-dependent intracellular bacterial community development

Tacrolimus-loaded SLNs have advanced further than many other systems, with some formulations evaluated in Phase I trials for inflammatory skin conditions, including psoriasis and atopic dermatitis