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Prolonged continuous intravenous infusion of the dipeptide l-alanine- l-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury

Second, translational development should focus on dual-functional nanocarriers incorporating A-targeting peptides and RVG29 brain-homing peptides, delivering GPX4 activators or iron chelators with pH/ROS-responsive release to ensure lesion-specific delivery and avoid neurotransmitter synthesis impairment from non-specific iron depletion

Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain

7), consistent with the observed half-maximal degradation concentration (DC 50 ) values (MV4-11 1000 mm 3 within 12 days (Supplementary Fig

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Ferroptosis-related detection Mitochondrial membrane potential detection Mitochondrial membrane potential was measured by fluorescence microscopy of cells using Mitochondrial Membrane Potential Assay Kit with TMRE (Beyotime, China)