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Slightly different from class I HDACs, Sirt1 ~ 3 have been reported to facilitate a greater degree of delactylation in non-histone proteins compared to histone proteins, which may be attributed to the subcellular localization of Sirt1 and Sirt2 being predominantly in the cytoplasm and mitochondrial matrix, respectively

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doi: 10.1158/0008-5472.CAN-15-2527 34 NakamuraJNakamuraM

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