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Several investigators have reported aberrant glutathione levels in schizophrenia patients, including medication nave subjects (44-48)

14,15 Similarly, patients manifesting prodromal RBD demonstrate a higher prevalence of peripheral neurodegeneration, including severe constipation and enteric -synuclein deposition

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Data availability The structural data that support the findings of this study have been deposited in the Protein Data Bank and EM Data bank

44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops