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However, the combination of these elements in a single transgene yielded very low levels of -globin gene expression in the erythroid cells of mice undergoing transplantation with genetically modified HSCs bearing the transgene [122], [123], [124]

The current understanding is based on their separate mechanisms of action, which do not appear to directly conflict

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The a-DG-AuNPs induce the formation of micrometric bubbles when excited for 1.26 s at 760 nm with pulsed laser at power of 24 W/cm 2 because of NIR radiation harvesting of the fluorophore at laser power close to that observed for gold nanorods

Therefore, ATRA-ATO-NPs could greatly enhance the synergistic inhibition of ATRA and ATO on PIN1 expression in cancer cells, consistent with the above experimental results