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Bioavailability limitations require 2-3x higher doses for nasal versus injectable delivery , creating corresponding 2-3x cost increases that make nasal spray primarily appropriate for needle-phobic individuals or peptides specifically designed for nasal use

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Recent research has focused on a potential link between AMP-activated protein kinase (AMPK), a critical sensor of cellular energy status, and ferroptosis [55]

3.4.2 Trigonelline Trigonelline (TRG) is an alkaloid found in coffee beans, fenugreek seeds, various fruits and seeds