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Cigarette smoke not only contains high levels of oxidants, but it also activates oxidant producing pathways in the lungs [1, 2]

(2016) utilized the plasma-free amino acid dose-response method to compare the bioavailability of methionine in Smartamine M versus Mepron, finding that Mepron had 28% of the bioavailability of Smartamine

References 1 BrayFFerlayJSoerjomataramISiegelRLTorreLAJemalA

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Toxicokinetic analysis showed a dose-dependent increase in plasma rotigotine concentrations