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Ethical considerations, such as the use of anaesthesia and euthanasia methods in advanced embryos, urge the application of the 3Rs principle (Replacement, Reduction, Refinement) and the development of protocols to ensure embryo and hatchling welfare and the responsible use of these organisms

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Clemastine improves hypomyelination in rats with hypoxic-ischemic brain injury by reducing microglia-derived IL-1 via P38 signaling pathway

Zhang R, Pan T, Xiang Y, Zhang M, Xie H, Liang Z, et al

[DOI] [PubMed] [Google Scholar] 148.Imbernon-Moya A., Ortiz-de Frutos F.J., Sanjuan-Alvarez M., Portero-Sanchez I., Merinero-Palomares R., Alcazar V

By understanding how they work, we can learn from them