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The intestinal adaptation after bariatric surgery is associated with increased recycling of BAs, which plays a protective role against obesityrelated comorbidities ( Similar effects are observed in rats with dietinduced obesity ( VSG is a surgical procedure that is associated with an increase in serum BAs and a decrease in gene expression of the GPBAR1 receptor in the white adipose tissue, independent from dietetic variations ( When BAs bind ileal GPBAR1, peptide YY (PYY) circulating levels as well as GLP1 and GLP2 increase playing an anorexigenic effect (i.e., appetite reduction), as well as GLP1 and GLP2 ( via the FXRFXR response element (FXRE) signaling ( The gut microbiota might also be involved in this crosstalk between BAs and glucose and lipid metabolism ( Gut microbiota is responsible for the deconjugation, oxidation, sulfation, and dihydroxylation of the primary BAs to the secondary BAs ( Figure 1 )

Significance was set at P 0.50) are reported

Bifidobacterium is significantly reduced, where these strains produce acetate and lactate, lower intestinal pH, and inhibit the growth of harmful bacteria (Dimidi et al., 2017)

10.1073/pnas.2017152117 139 YuanH.LiX.ZhangX.KangR.TangD

Genes and regulatory pathways involved in persistence of dormant micro-tumors

Phosphorylation of human insulin receptor substrate-1 at serine 629 plays a positive role in insulin signaling