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OC26 Soldatovic I

The pathogenesis of AD is complex and not completely understood

Biological chemistry of hydrogen sulfide and persulfides

This triggers brain inflammation, leading to symptoms like hyperactivity, seizures, altered consciousness, encephalopathy, coma, and psychomotor issues.79 80,81 Cancer Growth and Metastasis Elevated GGT levels degrade glutathione (GSH), increasing hydrogen sulfide (H2S) production and reducing antioxidant activity

Ghanizadeh A, Akhondzadeh S, Hormozi M, Makarem A, Abotorabi-Zarchi M, Firoozabadi A (2012) Glutathione-related factors and oxidative stress in autism, a review

Loss of normal SQOR function directly disrupts hydrogen sulfide (H 2 S) homeostasis, leading to mitochondrial dysfunction, and also exacerbates redox imbalance in the kidney, triggers innate immune activation, and reshapes cellular metabolism (for example, by affecting protein stability and causing excessive ubiquitin-mediated degradation)