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Cardiovascular agents such as hydrochlorothiazide, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, beta blockers, and statins are among the most commonly reported culprits

and hot beverages, which raise skin temperature

Due to the limited data, it should be avoided by anyone who is pregnant, breastfeeding, or undergoing active cancer treatment

Oral capsules and liquids must fight their way through stomach acids and liver enzymes, resulting in a microscopic absorption rate of only 1% to 10%