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Meanwhile, excessive metabolites from supersulfides, such as H 2 S, are catalyzed by SQR to mitigate sulfide toxicity [46] (Figure 3)

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These proteins may promote DNA demethylation by binding to CpG rich regions to prevent unwanted DNA methyltransferase activity, and by converting 5-mC to 5-hmC, 5-hmC to 5-fC (5-formylcytosine), and 5-fC to 5-caC (5-carboxylcytosine) through hydroxylase activity