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DSIP: DSIP has limited human safety data from small clinical studies

The crucial o-sulfonamidophenol group resides in the pocket created by the C-terminal helix and loop, forms a salt bridge with Gln207, and stabilizes its molecular conformation through - interactions with Trp8/206

These therapies are highly effective for advanced melanoma but frequently cause immune-related adverse events requiring corticosteroid management

Although the National Institute of Health (NIH) still claims that GSH deficiency is very rare, there is growing number of reputable sources that state quite the opposite