Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: post hoc analysis of a randomized controlled 4.3 year trial
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NND was positive in only one test system, i.e., HepG2 cells with hamster S9-mix, already at the lowest tested concentration (5 M)
The applicant explained that the study has enrolled 19 study participants with recurrent cubital tunnel syndrome following a failure to maintain the functional improvements from their primary decompression procedure, allowing participants to serve as their own in-patient controls for analysis of the treatment effect of repeating the decompression procedure with the addition of the Axoguard HA+ Nerve Protector TM
Gradual titration from the lowest dose is always the safest approach when introducing a new compound with a different mechanism of action
Fatigue scores correlate with other self-assessment data, but not with clinical and biomarker parameters, in CIS and RRMS