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This agent differs from earlier therapies that were designed to reduce myocardial loading or induce neurohumoral blockade

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Massa et al., 2010)

H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

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Week five through six: Move to daily application if every-other-day causes no issues