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There is not enough research to confirm safety, so it is generally not recommended

PYC modulates TGF-1 expression and the phosphorylation of SMAD (mothers against decapentaplegic homolog) family member 2/3, effectively suppressing these signaling pathways (Sproston and Ashworth, 2018), further highlighting its anti-inflammatory potential ( Collectively, these reports reveal the potent anti-inflammatory and immunomodulatory effects of PYC (Figure 1), warranting further clinical trials to evaluate its therapeutic efficacy against various infections, including viral infections that induce host inflammation and immune dysregulation

Nitric Oxide Synthase (eNOS/iNOS) Pathway Regulation Stimulates NO production through eNOS/iNOS activation : BPC-157 upregulates nitric oxide synthesis in vascular tissue and restores endothelial homeostasis, as shown in ischemic and inflammatory models 3,4

It seems there is no real logic apart from the fact that vitamin C is present in some of them

Reply to Dietary Glucosinolates and Risk of Type 2 Diabetes in 3 Prospective Cohort Studies

A targetable pathway in neutrophils mitigates both arterial and venous thrombosis