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The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity

Sulforaphane alleviates scopolamine-induced memory impairment in mice

Estrogen receptor activation in bone counters osteoclastic resorption, thereby potentially slowing bone mineral density loss that accelerates after natural or surgical menopause

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But, the active sites also bind weakly to other amino acids and nucleotides, partially blocking the action of the enzyme